MYC and colonic neoplasm: Both c-myc and cyclin D1 are overexpressed in colon cancer cells (Moradifard et al., 2022; Wang et al., 2017; Musgrove et al., 2011; Santarius et al., 2010; Böckelman et al., 2012), and we found that AFC downregulated both c-myc and cyclin D1 at the protein (Figures 7A-D) and mRNA levels (Figures 7E, F) in HCT116 and LoVo cells.