PLVAP and retinopathy of prematurity: PLVAP is believed to plays a significant role in regulating vascular permeability and be linked to compromised barrier function in several retinal disorders in various retinal diseases, such as wet AMD, DR and retinopathy of prematurity (ROP) (Wisniewska-Kruk et al., 2014; Wisniewska-Kruk et al., 2016; Nakagami et al., 2019).