There is a mounting body of evidence suggesting that SREBP2-mediated cholesterol biosynthesis plays a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis (Calvisi et al., 2011; Che et al., 2020; Chen W. et al., 2022; Saito et al., 2023; Wang et al., 2023). This evidence concerns the gene SREBF2 and hepatocellular carcinoma.