The activation of NLRP3 inflammasome promotes the secretion of Caspase-1, which secretes downstream cytokines, NF-κB, TNFα, and other pro-inflammatory cytokines, and then induces apoptosis, which NLRP3 cascade has been implicated CNS disorders such as depression (Beckwith et al., 2020). This evidence concerns the gene TNF and central nervous system disorder.