Based on GSE114517 dataset, a strong negative correlation between VRFCs of phages and PD-related human gene expressions (tyrosine hydroxylase, TH, a dopamine synthetase, etc.)was detected in the SN of PD patients; pathways affected by these phages were similar in PD pathophysiology, although the phages belong to different genera and families (Fig. S2A to C and Tables S4 to S6). Here, TH is linked to Parkinson disease.