The administration of NSC-sEVs via bilateral ventricular injection in APP/PS1(B6; C3-Tg) mice attenuated AD-related spatial learning and memory deficits, as well as increased expression levels of mitochondrial function-related factors (PGC1α, NRF1, NRF2, and Fis1) and synapse-associated proteins (synaptophysin, PSD95, MAP2). The gene discussed is SYP; the disease is Alzheimer disease.