COMMD1 and Sepsis: In studies examining the role of COMMD1 in LPS- or cecal ligation and puncture (CLP)-induced sepsis and DSS-induced colitis models, mice with a specific disruption of Commd1 in myeloid cells exhibited much stronger inflammatory responses, characterized by overproduction of proinflammatory cytokines and higher disease severity, compared to their wild-type littermates (25).