PRF1 and neoplasm: Activated Vδ2+ T cells exert antitumor effects through multiple mechanisms, including but not limited to direct killing of tumor cells via NK cell receptors, induction of tumor cell apoptosis through apoptosis-related ligands (TRAIL/FASL), lysis of tumor cells through secreted granzyme/perforin, and killing of tumor cells through the antibody-dependent cell-mediated cytotoxicity (ADCC) effect.