Compared with the WT-CIA group, the CD47-KO-CIA group exhibited significant decreases in the swelling of the left and right hind paws, arthritis and clinical scores, as well as levels of rheumatoid factor (RF), TNF-α, total leukocytes, neutrophils, and platelets in the blood (Figures 2A–J). The gene discussed is CD47; the disease is Arthritis.