Quantitative analysis of serum levels of VEGF in patients with SSc and healthy controls showed that serum VEGF levels were significantly higher in SSc patients and correlated with the extent and severity of skin fibrosis and nailfold capillary loss, suggesting that high VEGF levels may promote in the capillary damage in SSc and may correlate with the extent and severity of the fibrotic process and with disturbed angiogenesis (191–193). This evidence concerns the gene VEGFA and systemic sclerosis.