While the signaling of TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF receptor superfamily member 11 (TNFRSF11, RANKL) induces CRC cells to produce CC motif chemokine ligand 20 (CCL20), leading to Treg recruitment through CCL20-CCR6 pathway and promoting tumor stemness and malignant progression (81). This evidence concerns the gene TNFRSF11A and neoplasm.