Among the 223 genes upregulated with both XIST and MN1 knockdown, 15 genes showed significant differential expression between male and female BC tissues, with ARL8B, EIF5, GGA2, GNL3, SAR1A, SEC23IP, VAMP3, and VDAC2 being significantly more highly expressed in male BC tissues than in female BC tissues (Figure 7G). The gene discussed is MN1; the disease is breast cancer.