Therefore, given the increased expression of both NF-kB and GLRX1 in FRDA fibroblasts and moving from our recent evidence of a different TLR4 modulation in two sisters with FRDA (Petrillo et al., 2024), we wonder if TLR4 could be up-regulated in FRDA fibroblasts. This evidence concerns the gene NFKB1 and Friedreich ataxia.