TXN and Friedreich ataxia: As shown in Figure 2, significant increases of both enzymes have been observed in FRDA cells, when compared to healthy subjects, either as mRNA transcript levels (Figures 2A,B) and as protein amounts (Figures 2C–E), thus suggesting a dual role for TRX1 and GLRX1 in FRDA, as modulators of redox homeostasis but also as possible contributors in the inflammatory response.