Emerging evidences report a role for ferroptosis in FRDA (Cotticelli et al., 2019; La Rosa et al., 2020b), with Nrf2 as main regulator of several genes directly or indirectly involved in modulating it (La Rosa et al., 2020b; Paupe et al., 2009; D’Oria et al., 2013; Shan et al., 2013; Petrillo et al., 2017, 2019, 2021; La Rosa et al., 2019, 2020b) and, importantly, the Nrf2 deficiency has been shown to activate the pathway of NF-κB, leading to increased production of inflammatory factors (Wardyn et al., 2015; Gao et al., 2022). This evidence concerns the gene NFKB1 and Friedreich ataxia.