Starting from the negative cross-talk between the two main regulators of oxidative stress and inflammation (Wardyn et al., 2015; Gao et al., 2022; van der Horst et al., 2022), we analyzed levels of NF-kB and IL-1β in fibroblasts of n.3 FRDA patients and n.3 healthy subjects, to understand if the frataxin-mediated Nrf2 decrease might be followed by an inflammatory response in FRDA. The gene discussed is FXN; the disease is Friedreich ataxia.