The Consensus Molecular Subtypes (CMS) is a widely used molecular classification method in colorectal cancer, which divides tumors into four subgroups (CMS1-4) based on mRNA gene expression patterns:CMS1 (MSI immune subtype): Associated with MSI, dDNA mismatch repair, BRAF V600E mutation, hypermutation (Abnormally accelerated gene mutation rates, often in immune cells to rapidly generate antibody variants), CIMP, and primarily observed in females. This evidence concerns the gene BRAF and colorectal cancer.