After 2 cycles of BEP chemotherapy, the reexamination CT scan revealed that the cancer thrombus in the inferior vein had enlarged(Figures 2B, E), the pulmonary nodules had grown larger(Figure 3B), AFP was 4.64 ug/L, B-HCG was 12.86 IU/L and LDH was 214U/L, the comprehensive efficacy was assessed as progress disease (PD), and the patient presented with myelosuppression (leukocyte 1.29 x 109). The gene discussed is AFP; the disease is cancer.