HFpEF: heart failure with preserved ejection fraction; OSA: obstructive sleep apnea; CPAP: continuous positive airway pressure; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; LV: left ventricle; SGLT2: sodium-glucose cotransporter 2; MRA: mineralocorticoid receptor antagonist. The gene discussed is ACE; the disease is obstructive sleep apnea syndrome.