HFpEF: heart failure with preserved ejection fraction; OSA: obstructive sleep apnea; CPAP: continuous positive airway pressure; NT-proBNP: N-terminal pro-B-type natriuretic peptide; BNP: B-type natriuretic peptide; hs-CRP: high-sensitivity C-reactive protein. The gene discussed is NPPB; the disease is heart failure.