In this study, clinical indicators such as age, BMI, medication use, thyroid hormone levels (T3, T4, TSH), and temperament traits were examined in relation to depression and anxiety levels. Our investigation revealed that anxiety levels were significantly elevated in the hyperthyroidism group compared to the control group (HADS-Anxiety: 6.49±3.59 vs. 1.95±0.22; p<0.001), whereas the difference in HADS-Depression scores between the two groups did not reach statistical significance (6.93±4.74 vs. 5.08±3.21; p = 0.070). This evidence concerns the gene TG and depressive disorder.