Inhibition of kynurenine 3-monooxygenase (KMO) significantly suppressed XA elevation and attenuated both oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury and ligation-induced myocardial ischemia injury, suggesting XA's potential utility as a ferroptosis marker in CAD. The gene discussed is KMO; the disease is coronary artery disorder.