SIRT1 and Cognitive impairment: In agreement with the pathological roles of neuronal C/EBPβ/AEP signaling in aging and AD pathogenesis, nicotinamide ribose (NR) ameliorates cognitive impairments in aged mice and AD mouse models.[44] NMN also relieves cognitive impairment and amyloid deposition in AD mouse models.[16, 17] Hence, NAMPT may exert these beneficial effects via NAD+‐activated SIRT1, consistent with previous reports that NAMPT enzymatic activity stimulates the synthesis of NAD+, which is an essential cofactor of SIRT deacetylases, partially explaining why #11a performs a better anti‐aging effect than NMN.[40]