The overexpression of LHX1, which is a member of the LIM family of homeodomain proteins, can lead to oncogenic activity, thereby augmenting malignant cellular behaviors.[27] Conversely, NKX2‐5 serves as a tumor suppressor in the context of colorectal cancer.[28] However, both LHX1 and NKX2‐5 exhibit oncogenic properties in ESCC, thus underscoring the intricate and context‐specific nature of homeobox gene functionality in cancer development. The gene discussed is NKX2-5; the disease is colorectal cancer.