Interestingly, ubiquitin‐like protein with plant homeodomain and ring finger domains 1 (UHRF1) emerged as a compelling target due to its critical role in tumorigenesis and potential as an attractive drug target for treatment.[18, 19] Subsequent RT‐qPCR and Western blot results revealed a significant downregulation of UHRF1 expression in ESCC cells upon NKX2‐5 and LHX1 silencing (Figure 4E,F; Figure S5B,C, Supporting Information). Here, UHRF1 is linked to esophageal squamous cell carcinoma.