The overexpression of LHX1, which is a member of the LIM family of homeodomain proteins, can lead to oncogenic activity, thereby augmenting malignant cellular behaviors.[27] Conversely, NKX2‐5 serves as a tumor suppressor in the context of colorectal cancer.[28] However, both LHX1 and NKX2‐5 exhibit oncogenic properties in ESCC, thus underscoring the intricate and context‐specific nature of homeobox gene functionality in cancer development. This evidence concerns the gene PDLIM5 and esophageal squamous cell carcinoma.