IFNG and esophageal squamous cell carcinoma: Furthermore, pathway analysis revealed that DEGs in the high‐activity group were enriched in functions related to immunosuppressive responses or immune evasion processes, such as allograft rejection and interferon gamma response (Figure 6D), thus suggesting that the high‐activity may promote ESCC tumorigenesis and progression by mediating the interaction between tumor cell and tumor microenvironment.