L1CAM and central nervous system cancer: Genes that are upregulated in IDHmut glioma, but are downregulated after CHIR99021 treatment included WNT7b, L1CAM, BEX1, and ID3, while genes that show downregulation in IDHmut glioma, but are upregulated after CHIR99021 included PDGFB, GLI3, and CCL2. TGF-β and γ-secretase inhibition showed a less substantial impact on the transcriptional landscape (Fig. 1d, Suppl.