CXCR4 and HIV infectious disease: In this regard, Penicillixanthone A (PXA), a marine-derived flavonoid dimer, which acts as a CCR5/CXCR4 dual-coreceptor antagonist with interesting applications in HIV infection [107] and various components from traditional Chinese herbs, such as sakosaponin A (SSA), which have shown potential as CXCR4 inhibitors have been described [108].