CXCL10 and hepatocellular carcinoma: As most liver cancer cells overexpress folate receptors on their surface, Duan et al. [110] developed folate-modified chitosan NPs encapsulating the human interferon-γ-inducible protein-10 (IP-10) gene, which inhibited the growth of the tumor, extended survival in nude mice receiving subcutaneous transplantation of human HCC, and specifically bound to the folate receptor on HCC cells to facilitate the IP-10 expression.