Moreover, compared to the result observed for serum AFP (Supplementary Fig. S5), the HCC EV Digital Scores demonstrated improved performance in detecting early- or intermediate-stage HCC (AUROC = 0.85, 95% confidence interval [CI] = 0.76–0.94, sensitivity = 85.7%, specificity = 77.1%, Fig. 5F). The gene discussed is AFP; the disease is hepatocellular carcinoma.