IL1B and Sepsis: Similarly, we identified a cluster of PMN-like cells that exhibited a significant downregulation of pro-inflammatory genes including: Fcgrt, Tnfrsf25, Ptgdr, Il12a, Il1b, and these cells were significantly expanded seven days after CLP-induced sepsis in adult mice (p < 0.001 versus naive adult mice; Figure S5 B and S5 D).