Loss of RIPK1 in humans is further characterized as a primary immunodeficiency, resulting in peripheral T cell lymphopenia and enhanced T cell-mediated TNF and IFNy secretion (Sultan et al, 2022; Li et al, 2019; Dai et al, 2024; Uchiyama et al, 2019). This evidence concerns the gene RIPK1 and inborn error of immunity.