TNFSF8 and inflammatory bowel disease: Additionally, pathway analyses of CD4+ LP T cells scored highest for pathways associated with IBD and Th17 differentiation, especially based on upregulation of the type-3 immune response genes, such as Il17a, Tmem176a, Tmem176b, and Tnfsf8 (Ciofani et al, 2012; Drujont et al, 2016; Sun et al, 2010).