However, Ripk1-Cd4-Cre mice (Ripk1ΔCD4) developed age-related inflammatory disorders in the lungs, kidneys and heart, as well as sarcopenia and neurodegeneration (Imanishi et al, 2023; Wang et al, 2023), suggesting that RIPK1’s role in T cells is crucial for maintenance of tissue homeostasis in various tissues. Here, RIPK1 is linked to sarcopenia.