Further studies revealed that A2AR, which is widely expressed in the brain, directly interacts with NLRP3 to promote NLRP3 inflammasome assembly and activation in primary microglia, suggesting that inhibiting the interaction between A2AR and NLRP3 may reduce NLRP3 inflammasome assembly and activation, thereby alleviating neuroinflammation in posttraumatic brain injury [260]. The gene discussed is ADORA2A; the disease is injury.