In the context of high-fat diet-induced obesity, the acetylation of K255 on the α subunit of hydroxyl-CoA dehydrogenase triggers the mitochondrial localization of ASC, thereby activating the NLRP3 inflammasome and contributing to myocardial fibrosis [223]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.