Furthermore, the itaconate derivative 4-octyl itaconate alkylates C548 of NLRP3, thereby inhibiting the interaction between NLRP3 and NEK7 and abrogating NLRP3 inflammasome activation while demonstrating potential therapeutic benefits in CAPS and eosinophilic asthma [307, 378]. Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.