Interestingly, tumor necrosis factor receptor-associated factor 6 (TRAF6)-mediated K27-linked ubiquitination has been shown to modify proteins such as α-synuclein and DJ-1 in Parkinson’s disease and huntingtin in Huntington’s disease65,66, suggesting a role in neurodegenerative diseases. This evidence concerns the gene PARK7 and neurodegenerative disease.