GZMK and neoplasm: In fact, when compared with the 75,302 known virus-specific CDR3 sequences in VDJdb40, a fraction of GZMK+.DN-Tem (particularly GZMK+.C3.DN-Tem-CO) contained clonotypes restricted to known viral epitopes (Supplementary Fig. 4a), suggesting that not all GZMK+.DN-Tem are tumor specific.