CNR2 and neoplasm: Based on prior studies across multiple cancer models using CB2−/− mice that revealed consistent findings in MDSCs compared to the variable effects observed in T cells [8, 9], coupled with the prominent effect of OGP on the decumulation of MDSCs in ApcMin/+ mice, we assessed the effect of OGP on MDSC differentiation using bone marrow-derived cells cultured in the supernatant of CT26 cells—a colorectal carcinoma cell line—to mimic the tumor microenvironment.