IGFBP7 and breast cancer: Among the top ten genes driving the DN and BC clustering, we found six known histological markers (NEFM/-H/-L, GPNMB, VIM and CRYAB) and identified new candidates, such as SLC1A1 (glutamate transporter) and STMN2 (microtubule stability regulator) for DNs or MFAP4 (extracellular matrix protein enriched in progenitor cells) and IGFBP7 (insulin-like growth factor-binding protein 7 associated with cellular senescence) for BCs (Fig. 4h and Extended Data Fig. 8b).