Proteomic techniques, including gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, showed that the progression of pulmonary fibrosis was related to different pathways: glucose metabolism, lipid transport, glycoprotein metabolism, synthesis of sulfur compounds, and other energy metabolism, calcium ion transport were dominant in the early stage of fibrosis and the acute inflammatory stage. Here, ART4 is linked to pulmonary fibrosis.