In AD research, Wei et al. have created mouse models like the aging FAD4T, AD-specific APP/PS1, and mature microglial Dox-BV2, showing that H3K18la enhances NFκB signaling by upregulating the expression of Rela (p65) and NFκB1 (p50) [76]. This evidence concerns the gene NFKB1 and Alzheimer disease.