FTO and amyotrophic lateral sclerosis: Given that previous studies have shown FTO-mediated LINE1 RNA m6A demethylation plays a role in regulating chromatin state and gene expression during mouse oocyte and embryonic development64, and that retrotransposon reactivation has been observed in some ALS postmortem tissues62, it would be intriguing to explore in future studies whether Mettl14-mediated m6A impairment leads to retrotransposon reactivation through its interaction with chromatin state.