Barmada’s group reported that m6A hypermethylation modulates RNA binding by TDP43 and the disease pathogenesis of ALS and frontotemporal dementia (FTD)35, whereas Sun’s group indicated that globally reduced m6A levels in C9ORF72-associated ALS and FTD dysregulate RNA metabolism and contribute to neurodegeneration36. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.