SOD1 and amyotrophic lateral sclerosis: To scrutinize if compromised m6A writer expression leads to hypo-m6A in a human context, we differentiated three familial ALS iPSC lines (SOD1+/L144F, C9ORF72exp~800 G4C2, and TDP43G298S), together with their corresponding isogenic rescue controls (Ctrl #1 and Ctrl #2) and healthy control (Ctrl #3), into spinal MNs, and then profiled their m6A dynamics along the differentiation process under stress-induced conditions (illustrated in Fig. 1a, results in Fig. 1b–g)37,38.