TARDBP and amyotrophic lateral sclerosis: Barmada’s group reported that m6A hypermethylation modulates RNA binding by TDP43 and the disease pathogenesis of ALS and frontotemporal dementia (FTD)35, whereas Sun’s group indicated that globally reduced m6A levels in C9ORF72-associated ALS and FTD dysregulate RNA metabolism and contribute to neurodegeneration36.