Moreover, YTHDC1 RNAs have been discovered as binding to TDP43 protein in human SH-SY5Y neuroblastoma cells62, and peripheral blood sample transcriptional profiling of a huge heterogeneous ALS cohort (not only sporadic cases) revealed YTHDC1 to be differentially expressed63. This evidence concerns the gene YTHDC1 and amyotrophic lateral sclerosis.