In our proposed model (depicted in Supplementary Fig. 14b), we postulate that the aberrant down-regulation of the two m6A methyltransferases, namely METTL3 and METTL14, in ALS reflects an anomaly likely associated with the natural aging process compounded by unidentified exacerbating factors29. This evidence concerns the gene METTL3 and amyotrophic lateral sclerosis.