Lcn2 knockout (heterozygous or homozygous) mice presented decreased brain swelling, neutrophil infiltration, microglia activation, and neuronal death after being subjected to an intracerebral hemorrhage model.180 LCN2 also plays a role in stress-responsive neuroadaptation through hippocampal signaling modulation. This evidence concerns the gene LCN2 and intracerebral hemorrhage.