TNFRSF11B and myocardial infarction: There is more and more research data confirming that OPG is involved in cardiovascular disease processes and is a prognostic indicator of cardiovascular diseases, including atherosclerotic lesions, ischemic heart failure, and acute myocardial infarction.203 OPG exerts the above biological effects mainly by three signaling pathways in the endothelial cells.