Elevated serum levels of FGF23 are correlated with a heightened mortality risk in individuals suffering from acute heart failure207 or chronic heart failure.208 FGF23 can regulate cardiovascular function through various signaling pathways.209 One of the most important signaling pathways is the FGF23/FGFR1c/Klotho pathway. The gene discussed is FGF23; the disease is congestive heart failure.