LCN2 and Parkinson disease: Furthermore, they discovered that LCN2 ablation improved PD symptoms in mice, suggesting a possible pathogenic mechanism involving disruption of the nigrostriatal dopaminergic projections, abnormal locomotor behaviors, neurotoxic iron accumulation, and neuroinflammation.178 Therefore, developing regulatory methods for LCN2 or inhibitors of LCN2-induced neurotoxicity and neuroinflammation may be beneficial for treating PD.