HIVEP3 and obesity due to melanocortin 4 receptor deficiency: Schnurri-3 (SHN3, also known as Hivep3) is an adapter protein that functions intrinsically within osteoblasts to inhibit their bone-forming capabilities.159 The absence of Shn3 not only enhanced osteoblast activity but also alleviated obesity-related metabolic disorders.160Shn3−/− mice exhibited resistance to diet-induced obesity and an improvement in the browning of white adipose tissue.