BGLAP and Cognitive impairment: Complementary murine studies utilizing Runx2 haploinsufficient models delineate OCN’s role in mitigating age-associated cognitive impairment and anxiety phenotypes.170 These findings propose a dual therapeutic axis: (1) perinatal nutritional optimization to prevent developmental osteocalcin deficiency-linked neuropsychiatric sequelae; (2) OCN administration for reversing neurocognitive aging, independent of developmental programming.42