A number of PDAC risk loci have common SNPs or colocalize with GWAS for traits that influence PDAC risk: chr1q32.1/NR5A2/T2D, chr2p13.3/ETAA1/T2D/waist-hip-ratio (obesity measure), chr8q24.21/MIR1208/T2D, chr9q34/ABO/T2D/body fat percentage, chr12q24.31/HNF1A/Maturity-onset Diabetes of the Young/T2D, chr16q23.1/BCAR1/T2D, chr18q21.32/GRP/T2D/BMI/obesity (https://mvp-ukbb.finngen.fi/ and NHGRI GWAS Catalog19). This evidence concerns the gene NR5A2 and obesity due to melanocortin 4 receptor deficiency.