Murine hindlimb ischemia model is commonly used as a model of PAD to test new therapies with new materials or drugs.[30] Without any treatment, hindlimb ischemia worsened, and the limb got amputated; however, when treated with dECM/heparin cryogel (D1H1) and VEGF‐loaded dECM/heparin cryogel (D1H1_VEGF), blood perfusion was restored as time passed. Here, VEGFA is linked to peripheral arterial disease.