ACTC1 and cardiac hypertrophy: We identified 12 studies, of which 1 investigated the role of receptor tyrosine kinase signaling in development of cardiac hypertrophy,203 and 11 reported on mutations in fly equivalent sarcomere genes: myomesin (MYOM2) (n = 2),204,205MYH7 (n = 4),206, 207, 208, 209MYL2 (n = 1),18MYBPC3 (n = 2),47,210 and ACTC1 (n = 2).211