We identified a novel protective recessive association between a missense variant in SGLT4 (rs61746559), a sodium-glucose transporter with a possible role in the renin-angiotensin-aldosterone system, and hypertension (OR = 0.2, p = 3 × 10−8, dominance deviation p = 7 × 10−6). The gene discussed is SLC5A9; the disease is hypertensive disorder.