For example, it may be that rs66812091 in PNPLA3 has an additive effect on liver enzyme levels, leading to the accumulation of fatty acids that results in hepatic inflammation (i.e., the underlying quantitative trait), but a recessive effect on NAFLD (p = 2.4 × 10−12). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.