A prior study reported that silencing of AFG3L2 leads to the accumulation of PINK1 on the mitochondrial surface and Parkin recruitment, resulting in mitophagy induction.[19] We, therefore, performed transmission electron microscopy (TEM) to analyze the mitochondria in colonocytes from the AOM‐DSS‐induced CRC mouse model (Figure 1A) and in CRC cell lines overexpressing or knocked down for CRABP2. This evidence concerns the gene CRABP2 and colorectal carcinoma.