To investigate the role of CRABP2 in CRC progression, we next generated a conditional knockout mouse model specifically targeting CRABP2 in colonocytes (Crabp2ΔIEC; Figure S1C–G, Supporting Information) and subsequently established an azoxymethane and dextran sodium sulfate (AOM‐DSS)–induced[6] model of CRC in these animals (Figure1A). This evidence concerns the gene CRABP2 and colorectal carcinoma.