In colon tumors, PINK1 was shown to inhibit tumor growth by activating p53 to alter metabolic reprogramming.[5, 6] Interestingly, we also uncovered a paradoxical effect of cytoplasmic CRABP2 on mitophagy and CRLM, distinct from its nuclear role in promoting CRC cell proliferation. This evidence concerns the gene TP53 and colorectal carcinoma.