In addition, we performed immunoblot analysis on colonic epithelial cells isolated from AOM‐DSS–induced CRC model mice (Figure 1A) and cell lines treated with the protonophore carbonyl cyanide m‐chlorophenyl hydrazine (CCCP).[20] We found that CRABP2 deletion caused the accumulation of mitochondrial proteins (TOMM20, TIM23) and p62, with a decreased LC3‐II/I ratio, whereas CRABP2 overexpression had the opposite effect (Figure 4B; Figure S4A, Supporting Information). Here, CRABP2 is linked to colorectal carcinoma.