CDK5 and neoplasm: Thus, any shifts in the balance among the many cancer‐related pathways can drive distinct pathological outcomes.[30] For example, the Notch signaling pathway functions as a molecular switch in cancer, acting as either an oncogene or tumor suppressor depending on the context.[31] Moreover, similar to the dual, location‐dependent function of CRABP2, CDK5 acts as a tumor suppressor when localized in the nucleus but functions as an oncogene when present in the cytoplasm.[31]