CRABP2 and colorectal carcinoma: Tumorigenesis is a multistep process involving genetic mutations and alterations in numerous molecular mechanisms that influence tumor proliferation and apoptosis, thereby impacting tumor progression.[26] Here, we confirmed that CRABP2 is upregulated in tumor tissue from CRC patients, with higher levels of cytoplasmic relative to nuclear CRABP2, and that cytoplasmic and nuclear localization of CRABP2 lead to different biological effects.