To further investigate the roles of CRABP2 and RB1 in CRC progression, we performed adeno‐associated virus 9 (AAV9)‐mediated[16] knockdown of RB1 in Crabp2ΔIEC mice, followed by the establishment of the AOM‐DSS–induced CRC model (Figure S2H, Supporting Information). This evidence concerns the gene RB1 and colorectal carcinoma.