As a critical tumor suppressor, the inactivation or suppression of RB1 promotes cell division and proliferation, contributing to the development of various cancers.[15] We subsequently validated the interaction between CRABP2 and RB1 in co‐immunoprecipitation assays (Figure 2C; Figure S2E, Supporting Information) and performed immunofluorescence and immunoblotting analysis, revealing that CRABP2 and RB1 co‐localize within the cell nucleus (Figure 2D; Figure S2F,G, Supporting Information). The gene discussed is RB1; the disease is cancer.