NUPR1 and hepatocellular carcinoma: discovered that NUPR1 mediates tamoxifen resistance in breast cancer by upregulating the gene expression related to autophagy and drug resistance.[16] NUPR1 has been implicated in several biological characteristics, including ferroptosis,[18, 34] lipogenesis,[35] drug resistance,[17, 36] and angiogenesis[37] in HCC.