NUPR1 and hepatocellular carcinoma: demonstrated the inhibitory effects of ZZW‐115 on HCC.[18] Our study extends these findings by confirming that ZZW‐115 can improve the TME by inhibiting NUPR1 in macrophages and enhancing the efficacy of anti‐PD‐1 therapy, thereby advancing the understanding of ZZW‐115′s role in HCC treatment.