demonstrated that trifluoperazine dihydrochloride (TFP‐2HCL), an antipsychotic agent targeting NUPR1 in pancreatic cancer, binds to specific residues of the NUPR1 protein, inhibiting its function.[21] Building on this, we applied TFP‐2HCL to inhibit NUPR1 and observed the effect on macrophages. The gene discussed is NUPR1; the disease is pancreatic neoplasm.