Previous research by Liu and colleagues, which integrated pan‐cancer scRNA‐seq datasets, identified apolipoprotein E (APOE)+ macrophages as playing a critical role in mediating resistance to immunotherapy across various tumor types.[26] Our study revealed a strong positive correlation between NUPR1+ macrophages and APOE+ macrophages (Figure S9D, Supporting Information). This evidence concerns the gene NUPR1 and cancer.