NUPR1, or Nuclear Protein 1, is a transcriptional regulator involved in various cellular processes, including apoptosis, cell cycle regulation, and DNA repair,[14] and is often overexpressed in several cancers such as pancreatic,[15] breast,[16] and liver cancers,[17, 18] where it contributes to tumor survival, proliferation, and resistance to chemotherapy. The gene discussed is NUPR1; the disease is liver cancer.