APOE and neoplasm: conducted an integrative analysis of macrophages across multiple tumor types using single‐cell RNA sequencing data and demonstrated that APOE+ macrophages are closely associated with resistance to immunotherapy.[26] Our research reveals a strong correlation between NUPR1+ macrophages and APOE+ macrophages, underscoring the potential involvement of NUPR1 in shaping the immunosuppressive phenotype that underlies poor therapeutic response.