Pyroptosis is a form of programmed cell death mediated by the Gasdermin protein family (GSDM), characterized by inflammatory necrosis and the release of numerous cytokines.[39, 40, 41, 42] This process not only inhibits tumor cell growth but also enhances the anti‐tumor immune response through the recruitment of CD8+ T cells and natural killer cells. This evidence concerns the gene CD8A and neoplasm.