STING1 and neoplasm: In addition, Zn2+ enhances the recognition of tumor dsDNA by cGAS, which activates the STING signaling pathway and recruits immune cells to the tumor region, thereby remodeling the immunosuppressive microenvironment of iMWA residual tumors.[59, 60] The novel bimetallic Ca/Zn nanoagonists proposed in this study have the potential to enhance cellular inflammatory programmed necrosis of residual tumor cells following iMWA (Scheme 1).