Simultaneously, the bimetallic ions Ca2+ and Zn2+ disrupt the balance of oxidative stress in residual cancer cells through calcium deposition in mitochondria, which amplifies the production of ROS in the cytoplasm; and the combination of ROS and PZH (which inhibits the JAK2‐STAT3 signaling pathway) synergistically enhances the inflammation and necrosis of HCC cells. Here, STAT3 is linked to cancer.