During pyroptosis, double‐stranded DNA (dsDNA) interacts with metal ions, to activate the cGAS‐STING pathway.[43, 44] This activation induces the release of type I interferons (IFN), promotes dendritic cell (DC) maturation, and stimulates IFN secretion, significantly enhancing the efficacy of anti‐tumor immunotherapy. Here, IFNA1 is linked to neoplasm.