Key enzymes in lipogenesis, including stearoyl‐CoA desaturase (SCD), ATP citrate lyase (ACLY), and fatty acid synthase (FASN), are found upregulated in HCC,[7] and are regulated by sterol response element‐binding protein (SREBP, gene name SREBF) family.[8] Besides, the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway is crucial in promoting lipogenesis by regulating the expression of numerous lipogenic genes. The gene discussed is ACLY; the disease is hepatocellular carcinoma.