The migration and proliferation abilities were inhibited upon doxycycline treatment (Figure S3, Supporting Information), consistent with the known oncogenic role of H2A.Z in HCC as reported by previous studies.[17, 18] We also constructed VPS72‐knockdown Huh7 cell line and adopted it to the nude mice tumorigenicity assay. The gene discussed is VPS72; the disease is hepatocellular carcinoma.