VPS72, also referred to as YL1, serves as a common component in the mammalian TIP60 histone acetyltransferase complex of the INO80 family and the SRCAP (SWI2/SNF2‐related CBP activator protein) complex.[12] VPS72 functions as a histone chaperone, interacting with the H2A.Z‐H2B dimer and incorporating it into nucleosomes.[13, 14, 15] Given that the TIP60 and SRCAP complexes modulate the genome‐wide distribution of H2A.Z, aberrant VPS72 levels are thought to have a broad impact on the epigenetic landscape in HCC. This evidence concerns the gene VPS72 and hepatocellular carcinoma.