Given that AKT is not implicated in VPS72‐mediated mTORC1 activation, we evaluated the activity of two other upstream kinases, AMPK and ERK1/2, in VPS72‐overexpression (VPS72‐OE) and VPS72‐knockdown (VPS72‐KD) HCC cell lines. Here, AKT1 is linked to hepatocellular carcinoma.