Importantly, diacylglycerol (DG) is known as a double‐edged sword affecting tumor progression and can also regulate the TIME by activating CD8+ T cells and enhancing the cytotoxicity of natural killer (NK) cells.[57, 58] In sum, CXCL6 may significantly affect the content of key metabolites in CCA, which can further regulate tumor progression and TIME in return. This evidence concerns the gene CXCL6 and cholangiocarcinoma.