CD8A and cancer: We listed the top 30 metabolites with the largest differences and found that in sh‐CXCL6 cells, the most downregulated metabolites belonged to the phosphatidylcholine class (Figure 5E); phosphatidylcholines are reported to promote tumor cell proliferation and impair CD8+ T cell function.[52, 53] KEGG pathway analysis of these metabolites highlighted enrichment in cancer‐associated lipid pathways, including “Glycerophospholipid metabolism,” “Linoleic acid metabolism,” and “Arachidonic acid metabolism”[54, 55, 56] (Figure 5F).