Specifically, CXCR1/2 is expressed on TANs where they regulate TIME recruitment and NETs formation.[59, 60] Considering that CXCL6 is a chemokine that binds to these receptors, we studied its influence on TANs, applying IHC staining to detect the relationship between CXCL6 and TANs (CD10+) infiltration in two CCA TMAs. This evidence concerns the gene MME and cholangiocarcinoma.