As well as CD8+ T cells, which have been extensively studied, innate immune cells like tumor‐associated neutrophils (TANs) have also been shown to be closely related to tumor development and overall survival (OS) of patients.[13] The number of TANs has been associated with the prognosis of CCA surgery patients but the functional mechanisms have not been fully analyzed.[14] However, recent research revealed that TANs can form NETs in the extracellular space and greatly reshape the TIME,[15] suggesting an important way in which TANs might induce immunotherapy resistance in CCA. The gene discussed is CD8A; the disease is neoplasm.