The CXCL6 receptors, CXCR1 and CXCR2, are expressed on tumor and immune cells, and both are important in CXCL6 function.[82] We revealed that JAKs could be activated by CXCR1/2 and further phosphorylate STAT3 and PI3K proteins. The gene discussed is STAT3; the disease is neoplasm.