Lipid metabolism is one of the most prominent metabolic changes in cancer[74] and can generate the energy, biofilm components, and signaling molecules required for tumor cell proliferation, invasion, and metastasis while influencing the tumor microenvironment and responses to cancer treatments.[75] Lipidomic analysis enabled us to profile CXCL6‐related lipid metabolism changes in CCA and uncovered several core metabolites (Figure 5E–G), in particular the DGs ‘DG 12:0/14:0’, ‘DG (18:0/20:1/0:0)’, and ‘DG (18:0/0:0/18:0)’, which were found at the center of the metabolic network. This evidence concerns the gene CXCL6 and cancer.