Array-derived CHIP status was associated with both prevalent seropositive (N of prevalent seropositive cases, 5391; OR, 1.41; 95% CI; 1.08 to 1.83; P = 0.011) and seronegative (N of prevalent seronegative cases, 1066; OR, 1.93; 95% CI, 1.15 to 3.22; P = 0.012) RA (Fig. 3B). The gene discussed is STUB1; the disease is rheumatoid arthritis.