CHIP carrier status in DNMT3A was specifically associated with seropositive RA (OR, 1.81; 95% CI, 1.31 to 2.49; P < 0.001), whereas non-DNMT3A, non-JAK2 CHIP was associated with seronegative RA (OR, 3.60; 95% CI, 1.78 to 7.27; P < 0.001) in multivariable models (Fig. 3B). This evidence concerns the gene STUB1 and rheumatoid arthritis.