Having established a role for MBNL in IFNγ response, MHC Class I antigen presentation and T cell-mediated tumor cell killing in vitro, we hypothesized that downregulation of MBNL would cause reduced tumor immune infiltration in vivo. We transplanted NTC, 1KO, and DKO cells into immunocompetent mice (Fig 3A). The gene discussed is MBNL1; the disease is neoplasm.