Nonetheless, the function of SLC16A6 as a selective transporter for the release of ketone bodies from cells received supporting evidence from a recent study in which downregulation of SLC16A6 in the human colon cancer cell line Caco-2 decreased the extracellular levels of β-hydroxybutyrate without affecting the levels of lactate or pyruvate [62]. Here, SLC16A6 is linked to malignant colon neoplasm.