The active ingredients in Sinomenium acutum (beta-sitosterol, 16-epi-Isositsirikine, sinomenine, and stepholidine) have potential interactions with target proteins (caspase-3, prostaglandin-endoperoxide synthase 2, and transcription factor Jun) involved in the treatment of RA [111]. Here, PTGS2 is linked to rheumatoid arthritis.