C5 and myocardial infarction: Utilizing liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), Cheow et al. identified 252 upregulated extracellular vesicle proteins following myocardial infarction and proposed a potential panel for early myocardial infarction diagnosis, comprising apolipoprotein C-III, apolipoprotein D, platelet glycoprotein Ib alpha chain, complement C1q subcomponent subunit A, and complement C5 [79].