APP/PS1 is a double transgenic mouse model that overexpresses a chimeric mouse/human APP (Mo/HuAPP695swe) and a mutant human PS 1 (PS1-dE9) in neurons and provides an important tool for understanding the interaction between APP and PS1 in AD pathology during aging [40,41,42,43]. This evidence concerns the gene PSEN1 and Alzheimer disease.